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radiotelemetry N ω -nitro- l -arginine methyl ester renal hemodynamics glomerular filtration rate rat Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords radiotelemetry Nω-nitro-l-arginine methyl ester renal hemodynamics glomerular filtration rate rat Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Renal Physiology. In summary, DIO-associated GS is preceded by an increased hemodynamic sensitivity to l -NAME but not renal hypertrophy or hyperfiltration. Minimal effects of l -NAME were seen in OR ( n = 9) rats.
In contrast, N ω -nitro- l -arginine methyl ester ( l -NAME) administration in conscious, chronically instrumented OP ( n = 11) rats resulted in 15% and 39% increases in blood pressure and renal vascular resistance, respectively, and a 16% decrease in renal blood flow. Renal blood flow autoregulation was preserved in both OP ( n = 7) and OR ( n = 7) rats. 2.0 ± 0.1 μm 3 × 10 −6 ) were similar between OP ( n = 6) and OR ( n = 9) rats. Potential hemodynamic mechanisms of renal injury were assessed in additional groups of OP and OR rats fed a moderately high-fat diet for 3 mo. 128 ± 2 mmHg, P < 0.05) and substantial levels of proteinuria (63 ± 12 vs. OP ( n = 10) rats developed modest hypertension (142 ± 3 vs. Radiotelemetrically measured blood pressure, proteinuria, and GS were assessed.
Eight-week-old male obesity-prone (OP) and obesity-resistant (OR) rats (Charles River) were administered a moderately high-fat diet for 5 mo. We investigated if GS develops over longer periods of DIO and examined the potential role of hemodynamic mechanisms in its pathogenesis. GriffinĪbstract The diet-induced obesity (DIO) model is frequently used to examine the pathogenesis of obesity-related pathologies however, only minimal glomerulosclerosis (GS) has been reported after 3 mo. Polichnowski, Hector Licea-Vargas, Maria Picken, Jianrui Long, Rashmi Bisla, Geoffrey A. Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide.Īaron J.
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